Recombination in AIDS viruses
Identifieur interne : 001363 ( Main/Exploration ); précédent : 001362; suivant : 001364Recombination in AIDS viruses
Auteurs : David L. Robertson [Royaume-Uni] ; Beatrice H. Hahn [États-Unis] ; Paul M. Sharp [Royaume-Uni]Source :
- Journal of Molecular Evolution [ 0022-2844 ] ; 1995-03-01.
English descriptors
- KwdEn :
- Accession numbers, Aids research, Alternative tree topologies, Amino acid replacements, Approximate position, Breakpoint, Crossover, Crossover points, Diagrammatic representation, Different parts, Different phylogenetic histories, Different regions, Different subtypes, Divergent strains, Divergent viruses, Evolutionary relationships, Evolutionary trees, Gene, Gene sequences, Genetic diversity, Genetic elements, Genetic variation, Genome, Hahn, Horizontal branch lengths, Human immunodeficiency virus type, Human immunodeficiency viruses, Hybrid genomes, Immunodeficiency, Immunodeficiency virus, Informative site, Informative sites, Lentiviruses, Lineage, Long terminal, Louwagie, Major lineages, Major part, Mangabey, Mosaic, Mosaic genome, Mosaic genomes, Multiple sequence alignment, Nature hirsch, Other subtypes, Outgroup, Phylogenetic, Phylogenetic analyses, Phylogenetic analysis, Phylogenetic relationships, Phylogenetic trees, Phylogeny, Polymerase chain reaction, Possible relationships, Primary infection, Primate, Primate lentiviruses, Proc natl acad, Protein sequences, Putative, Putative recombination event, Recombinant, Recombinant lentiviruses, Recombination, Recombination event, Recombination events, Retroviral recombination, Retrovirus, Same cell, Sequence alignments, Sequence analysis, Sequence identity, Sequence subtype, Sequence subtypes, Simian immunodeficiency virus, Sivagmsab genome, Sooty mangabey, Sooty mangabeys, Subtype, Subtype classification, Subtype sequences, Subtypes, Such superinfection, Vanden haesevelde, Virol, Virology, Virus, West africa, West african.
- Teeft :
- Accession numbers, Aids research, Alternative tree topologies, Amino acid replacements, Approximate position, Breakpoint, Crossover, Crossover points, Diagrammatic representation, Different parts, Different phylogenetic histories, Different regions, Different subtypes, Divergent strains, Divergent viruses, Evolutionary relationships, Evolutionary trees, Gene, Gene sequences, Genetic diversity, Genetic elements, Genetic variation, Genome, Hahn, Horizontal branch lengths, Human immunodeficiency virus type, Human immunodeficiency viruses, Hybrid genomes, Immunodeficiency, Immunodeficiency virus, Informative site, Informative sites, Lentiviruses, Lineage, Long terminal, Louwagie, Major lineages, Major part, Mangabey, Mosaic, Mosaic genome, Mosaic genomes, Multiple sequence alignment, Nature hirsch, Other subtypes, Outgroup, Phylogenetic, Phylogenetic analyses, Phylogenetic analysis, Phylogenetic relationships, Phylogenetic trees, Phylogeny, Polymerase chain reaction, Possible relationships, Primary infection, Primate, Primate lentiviruses, Proc natl acad, Protein sequences, Putative, Putative recombination event, Recombinant, Recombinant lentiviruses, Recombination, Recombination event, Recombination events, Retroviral recombination, Retrovirus, Same cell, Sequence alignments, Sequence analysis, Sequence identity, Sequence subtype, Sequence subtypes, Simian immunodeficiency virus, Sivagmsab genome, Sooty mangabey, Sooty mangabeys, Subtype, Subtype classification, Subtype sequences, Subtypes, Such superinfection, Vanden haesevelde, Virol, Virology, Virus, West africa, West african.
Abstract
Abstract: Recombination contributes to the generation of genetic diversity in human immunodeficiency viruses (HIV) but can only occur between viruses replicating within the same cell. Since individuals have not been found to be simultaneously coinfected with multiple divergent strains of HIV-1 or HIV-2, recombination events have been thought to be restricted to the rather closely related members of the quasispecies that evolves during the course of HIV infection. Here we describe examples of both HIV-1 and HIV-2 genomes that appear to be hybrids of genetically quite divergent viruses. Phylogenetic analyses were used to examine the evolutionary relationships among multiple HIV strains. Evolutionary trees derived from different genomic regions were consistent with respect to most of the viruses investigated. However, some strains of HIV-1 and HIV-2 exhibited significantly discordant branching orders indicative of genetic exchanges during their evolutionary histories. The crossover points of these putative recombination events were mapped by examining the distribution of phylogenetically informative sites supporting alternative tree topologies. A similar example of a recombinant simian immunodeficiency virus identified in West African green monkeys has also been described recently. These results indicate that coinfection with highly divergent viral strains can occur in HIV-infected humans and SIV-infected primates and could lead to the generation of hybrid genomes with significantly altered biological properties. Thus, future characterization of primate lentiviruses should include careful phylogenetic investigation of possible genomic mosaicism.
Url:
DOI: 10.1007/BF00163230
Affiliations:
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Sharp</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Genetics, University of Nottingham, Queens Medical Centre, NG7 2UH, Nottingham</wicri:regionArea><orgName type="university">Université de Nottingham</orgName><placeName><settlement type="city">Nottingham</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Nottinghamshire</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Molecular Evolution</title><title level="j" type="abbrev">J Mol Evol</title><idno type="ISSN">0022-2844</idno><idno type="eISSN">1432-1432</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>New York</pubPlace><date type="published" when="1995-03-01">1995-03-01</date><biblScope unit="volume">40</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="249">249</biblScope><biblScope unit="page" to="259">259</biblScope></imprint><idno type="ISSN">0022-2844</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-2844</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Accession numbers</term><term>Aids research</term><term>Alternative tree topologies</term><term>Amino acid replacements</term><term>Approximate position</term><term>Breakpoint</term><term>Crossover</term><term>Crossover points</term><term>Diagrammatic representation</term><term>Different parts</term><term>Different phylogenetic histories</term><term>Different regions</term><term>Different subtypes</term><term>Divergent strains</term><term>Divergent viruses</term><term>Evolutionary relationships</term><term>Evolutionary trees</term><term>Gene</term><term>Gene sequences</term><term>Genetic diversity</term><term>Genetic elements</term><term>Genetic variation</term><term>Genome</term><term>Hahn</term><term>Horizontal branch lengths</term><term>Human immunodeficiency virus type</term><term>Human immunodeficiency viruses</term><term>Hybrid genomes</term><term>Immunodeficiency</term><term>Immunodeficiency virus</term><term>Informative site</term><term>Informative sites</term><term>Lentiviruses</term><term>Lineage</term><term>Long terminal</term><term>Louwagie</term><term>Major lineages</term><term>Major part</term><term>Mangabey</term><term>Mosaic</term><term>Mosaic genome</term><term>Mosaic genomes</term><term>Multiple sequence alignment</term><term>Nature hirsch</term><term>Other subtypes</term><term>Outgroup</term><term>Phylogenetic</term><term>Phylogenetic analyses</term><term>Phylogenetic analysis</term><term>Phylogenetic relationships</term><term>Phylogenetic trees</term><term>Phylogeny</term><term>Polymerase chain reaction</term><term>Possible relationships</term><term>Primary infection</term><term>Primate</term><term>Primate lentiviruses</term><term>Proc natl acad</term><term>Protein sequences</term><term>Putative</term><term>Putative recombination event</term><term>Recombinant</term><term>Recombinant lentiviruses</term><term>Recombination</term><term>Recombination event</term><term>Recombination events</term><term>Retroviral recombination</term><term>Retrovirus</term><term>Same cell</term><term>Sequence alignments</term><term>Sequence analysis</term><term>Sequence identity</term><term>Sequence subtype</term><term>Sequence subtypes</term><term>Simian immunodeficiency virus</term><term>Sivagmsab genome</term><term>Sooty mangabey</term><term>Sooty mangabeys</term><term>Subtype</term><term>Subtype classification</term><term>Subtype sequences</term><term>Subtypes</term><term>Such superinfection</term><term>Vanden haesevelde</term><term>Virol</term><term>Virology</term><term>Virus</term><term>West africa</term><term>West african</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Accession numbers</term><term>Aids research</term><term>Alternative tree topologies</term><term>Amino acid replacements</term><term>Approximate position</term><term>Breakpoint</term><term>Crossover</term><term>Crossover points</term><term>Diagrammatic representation</term><term>Different parts</term><term>Different phylogenetic histories</term><term>Different regions</term><term>Different subtypes</term><term>Divergent strains</term><term>Divergent viruses</term><term>Evolutionary relationships</term><term>Evolutionary trees</term><term>Gene</term><term>Gene sequences</term><term>Genetic diversity</term><term>Genetic elements</term><term>Genetic variation</term><term>Genome</term><term>Hahn</term><term>Horizontal branch lengths</term><term>Human immunodeficiency virus type</term><term>Human immunodeficiency viruses</term><term>Hybrid genomes</term><term>Immunodeficiency</term><term>Immunodeficiency virus</term><term>Informative site</term><term>Informative sites</term><term>Lentiviruses</term><term>Lineage</term><term>Long terminal</term><term>Louwagie</term><term>Major lineages</term><term>Major part</term><term>Mangabey</term><term>Mosaic</term><term>Mosaic genome</term><term>Mosaic genomes</term><term>Multiple sequence alignment</term><term>Nature hirsch</term><term>Other subtypes</term><term>Outgroup</term><term>Phylogenetic</term><term>Phylogenetic analyses</term><term>Phylogenetic analysis</term><term>Phylogenetic relationships</term><term>Phylogenetic trees</term><term>Phylogeny</term><term>Polymerase chain reaction</term><term>Possible relationships</term><term>Primary infection</term><term>Primate</term><term>Primate lentiviruses</term><term>Proc natl acad</term><term>Protein sequences</term><term>Putative</term><term>Putative recombination event</term><term>Recombinant</term><term>Recombinant lentiviruses</term><term>Recombination</term><term>Recombination event</term><term>Recombination events</term><term>Retroviral recombination</term><term>Retrovirus</term><term>Same cell</term><term>Sequence alignments</term><term>Sequence analysis</term><term>Sequence identity</term><term>Sequence subtype</term><term>Sequence subtypes</term><term>Simian immunodeficiency virus</term><term>Sivagmsab genome</term><term>Sooty mangabey</term><term>Sooty mangabeys</term><term>Subtype</term><term>Subtype classification</term><term>Subtype sequences</term><term>Subtypes</term><term>Such superinfection</term><term>Vanden haesevelde</term><term>Virol</term><term>Virology</term><term>Virus</term><term>West africa</term><term>West african</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Recombination contributes to the generation of genetic diversity in human immunodeficiency viruses (HIV) but can only occur between viruses replicating within the same cell. Since individuals have not been found to be simultaneously coinfected with multiple divergent strains of HIV-1 or HIV-2, recombination events have been thought to be restricted to the rather closely related members of the quasispecies that evolves during the course of HIV infection. Here we describe examples of both HIV-1 and HIV-2 genomes that appear to be hybrids of genetically quite divergent viruses. Phylogenetic analyses were used to examine the evolutionary relationships among multiple HIV strains. Evolutionary trees derived from different genomic regions were consistent with respect to most of the viruses investigated. However, some strains of HIV-1 and HIV-2 exhibited significantly discordant branching orders indicative of genetic exchanges during their evolutionary histories. The crossover points of these putative recombination events were mapped by examining the distribution of phylogenetically informative sites supporting alternative tree topologies. A similar example of a recombinant simian immunodeficiency virus identified in West African green monkeys has also been described recently. These results indicate that coinfection with highly divergent viral strains can occur in HIV-infected humans and SIV-infected primates and could lead to the generation of hybrid genomes with significantly altered biological properties. Thus, future characterization of primate lentiviruses should include careful phylogenetic investigation of possible genomic mosaicism.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Nottinghamshire</li></region><settlement><li>Nottingham</li></settlement><orgName><li>Université de Nottingham</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Robertson, David L" sort="Robertson, David L" uniqKey="Robertson D" first="David L." last="Robertson">David L. Robertson</name></region><name sortKey="Sharp, Paul M" sort="Sharp, Paul M" uniqKey="Sharp P" first="Paul M." last="Sharp">Paul M. Sharp</name></country><country name="États-Unis"><noRegion><name sortKey="Hahn, Beatrice H" sort="Hahn, Beatrice H" uniqKey="Hahn B" first="Beatrice H." last="Hahn">Beatrice H. Hahn</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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